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Multiple Sclerosis Centers of Excellence


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Fingolimod (Gilenya®)

Fingolimod (Gilenya®) is the first oral agent approved by the FDA in 2010 as a disease modifying treatment for MS. It is given at a dose of .5 mg capsule taken once per day by mouth with or without food. It is a new class of MS medication called a sphingosine 1-phosphate receptor modulator. The medication mechanism of action can reduce neurodegeneration by reducing inflammatory damage to nerve cells. Side effects patients may develop include bradycardia, atrioventricular block, hypotension and other cardiac manifestations. Patients must be followed closely after an initial dose to recognize and treat these events if they occur. Other adverse events which require further investigation include development of macular edema, neoplasms and infections. Individuals who have questions about fingolimod should contact their healthcare provider.

For More Information

Fingolimod (Gilenya®) Monograph
Fingolimod (Gilenya®) Criteria for Use
Gilenya® (website for patients and professionals)









Updated: Setember 2015