Vaccines and Multiple Sclerosis: A Practical Guide - Multiple Sclerosis Centers of Excellence
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Vaccines and Multiple Sclerosis: A Practical Guide

Kathy Tortorice, PharmD -- VA National Pharmacy Benefits Management Service

Vaccines are important for preventing other illnesses. Preventive care is also an important part of MS management. You may wonder about links between MS and vaccines. Are vaccines safe to use in people with MS? Do vaccines cause MS? Are they safe for me? Should I have them? This article clarifies that vaccines do not cause MS and guides you in how vaccines are used safely by people with MS.

Do vaccines cause MS?

After mass vaccination programs for hepatitis B were begun, some people developed MS. This led to an investigation into a possible connection between the hepatitis B vaccine and MS. The Food and Drug Administration (FDA) reviewed the results of clinical studies used for approval of the hepatitis B vaccine and did not find any increase in MS. The World Health Organization Global Advisory Committee on Vaccine Safety states that “multiple studies and review panels have concluded that there is no link between MS and hepatitis B vaccination”. The US Centers for Disease Control and Prevention (CDC) and the National Network for Immunization Information also support the safety of the hepatitis B vaccine.

Why are vaccines important?

Vaccines are an important way to protect everyone from serious infectious diseases. Today’s vaccines are among the most successful and cost-effective public health tools available for preventing diseases. Thanks to vaccines, serious and often fatal diseases like polio are now distant memories for most Americans. In almost all cases, getting a vaccine is much safer than getting the disease itself. Currently, vaccines to protect children and adults from at least 17 diseases are available. Travelers to foreign countries, where uncommon diseases such as typhoid and yellow fever may be encountered, may need additional vaccines before their trips. Guidelines on vaccinations for people with MS have been established by the MS Council for Clinical Practice and by the CDC.

Several types of vaccines are available. Live, attenuated vaccines contain a version of the living microbe that has been weakened so it does not cause disease. Although live, attenuated vaccines are generally very effective, because they contain live microbes, they should not be given to people with damaged or weakened immune systems, such as those with HIV. Since there may be an increased risk with live, attenuated vaccines in people taking certain MS disease modifying medications, including natalizumab (Tysabri®), fingolimod (Gilenya®), teriflunomide (Aubagio®), and possibly dimethyl fumarate (Tecfidera®), people taking these medications should avoid live, attenuated vaccines when an alternative is available. 

Vaccines that are not live are inactivated (contain microbes killed by chemicals, heat, or radiation), subunits (contain only part of the microbe), toxoids (inactivated toxins), or conjugate (a subunit linked to a toxoid) vaccines. These non-live vaccines cannot cause disease and are therefore generally safe for use in people with MS. In addition to the active component of the vaccine (the part that induces disease protection), vaccines contain other substances. Anyone with a severe, life-threatening allergy to any component of a vaccine should not get that vaccine.

Non-Live Vaccines 

Live Vaccines 

  • Influenza Injectable (shot, including high dose)              
  • Pneumonia
  • Hepatitis A
  • Hepatitis B
  • Tetanus
  • Diphtheria
  • Pertussis
  • Influenza Nasal Spray (FluMist®)
  • Chickenpox
  • Shingles
  • Measles, Mumps, Rubella

Flu Vaccine

One of the most commonly used vaccines is influenza (flu) vaccine. Flu vaccines are one of the most important ones we should all be sure to get, because flu can be unpleasant and even fatal. There are several types of flu vaccine. The most familiar and commonly used one is the standard flu shot. The standard flu shot is an inactivated vaccine containing only killed flu viruses. The injectable flu vaccine is recommended for everyone over six months of age. It has been studied extensively in people with MS and is very safe. A high-dose, injected flu vaccine is available for people over age 65. This high-dose vaccine is also an inactivated vaccine. It has not been studied in people with MS and, at present, the CDC is only recommending the high-dose vaccine over the seasonal flu vaccine for people 65 years of ago or older.

Chicken Pox Vaccine (Variax)

There are some people who have never had chickenpox or the chickenpox vaccine. Because fingolimod, alemtuzumab, and ocrelizumab can increase the risk of chickenpox in people with MS, if you are going to use fingolimod and have not had chickenpox or the vaccine, the CDC recommends that you receive the varicella vaccination. The varicella vaccine is given in two doses four weeks apart. People with MS should not start fingolimod until at least one month after the last dose of the varicella vaccine.

Shingles (Zoster) Vaccine

The shingles vaccine (Zostavax®) protects people from shingles which is a reactivation of varicella zoster virus if you had chickenpox earlier in life. The CDC recommends adults 60 years or older receive the shingles vaccine. The shingles vaccine is a live vaccine; however, because most people have had chickenpox earlier in their lives and therefore already have the virus in their bodies, the risk of getting disease from the vaccine is much lower. If a person has had chickenpox or tests positive for the antibodies, the shingles vaccine would generally be safe and beneficial.

Pneumonia Vaccine

The pneumonia vaccine (Pneumovax®) protects people from pneumonia caused by the pneumococcus bacteria. This is a non-live, subunit vaccine. The pneumonia vaccine is recommended for people with compromised breathing or lung function, such as those who are wheelchair-dependent or bedbound, because they are more prone to pneumonia. This vaccine is generally safe for people with MS.

Other Vaccines

Both hepatitis A and hepatitis B vaccines are not live and are safe for people with MS. If you have not had these vaccines during childhood or as a condition of employment, discuss it with your health care provider to see if you need them. The measles, mumps, and rubella (MMR) vaccine is a live, attenuated vaccine generally given during infancy, after 1 year of age, and is recommended by CDC for the general population. Tetanus vaccine, which is often given as a combined vaccination with diphtheria (Td) or with both diphtheria and pertussis (Tdap), is not a live vaccine.

Overall, vaccines are safe and effective for people with MS and are important disease prevention tools. There are no concerns for use of non-live vaccines in people with MS. Live, attenuated vaccines should usually be avoided in people with MS when an effective, safe alternative is available. The use of live, attenuated vaccines should be avoided during and for two months after treatment with fingolimod because of the risk of infection. Additionally, vaccines should not be given during therapy with daclizumab, alemtuzumab, and ocrelizumab. If a live vaccine is required, therapy with these agents should not begin until 8 weeks after the vaccination. The risk of live, attenuated vaccines for people taking natalizumab, teriflunomide, and possibly dimethyl fumarate is uncertain; people on these medications should discuss the potential risk and benefits of live, attenuated vaccines, such as Zostavax®, with their healthcare provider. Vaccines should not be received during or within 4-6 weeks of an MS relapse. If you have any questions or concerns, please talk with your healthcare provider.