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Multiple Sclerosis Centers of Excellence

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Natalizumab (Tysabri®)

Natalizumab (Tysabri®) is a medication administered by IV infusion, over one hour every four weeks, for the treatment of relapsing forms of MS. Natalizumab is theorized to block molecular interaction of alpha-4-beta-integrin expressed by inflammatory cells with VCAM-1 on vascular endothelial cells. The humanized monoclonal antibody binds to alpha 4/beta 1 integrin on activated lymphocytes and monocytes, and blocks leukocyte passage across the blood brain barrier.

The medication must be prescribed through the Tysabri® Outreach: Unified Commitment to Health (TOUCH®) program.

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