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Multiple Sclerosis Centers of Excellence

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Multiple Sclerosis Centers of Excellence Research and Development

The MS Centers of Excellence facilitate research to improve the understanding of MS among Veterans with MS. We advance forward the VA’s research mission by providing a structure and environment that facilitates MS laboratory, clinical, and epidemiologic and health services research. We also provide an environment for the incubation of ideas, and provide a structured network to advance research quickly. Our local and national multi-site trials enhance collaboration among VA medical facilities and increase the participation of Veterans in research activities. We also provide mentoring for VA Career Development Grants and National Institute of Health Awards.

MSCoE West currently has over $10.3 million of research funding from various sources including the Veterans Affairs Rehabilitation Research and Development (VA RR&D) Service, National Institutes of Health (NIH), National Multiple Sclerosis Society (NMSS), and private industry. In addition, MSCoE West conducts several unfunded research and scholarly activities. To learn about VA MS researchers and research, visit our VA MS Researchers page. To learn about VA MS fellows, visit our MSCoE Fellows page.

Clinical Research

A multicenter randomized controlled trial of two group education programs for fatigue in MS: Long-term (12-month) follow-up at one site
MSCoE Author(s): Hugos CL, Cameron MH
Mult Scler. 2018 May 1:1352458518775920. PMID: 29761722

A multicenter randomized controlled trial of two group education programs for fatigue in MS: Short and medium-term benefits
MSCoE Author(s): Hugos C, Turner A, Haselkorn J, Cameron M
Mult Scler. 2017 Dec 1: 1352458517745723. PMID: 29226778

Anxiety is more important than depression in MS - No
MSCoE Author(s): Turner AP
Mult Scler. 2018 Apr;24(4):442-444. PMID: 29381113

Associations between bladder dysfunction and falls in people with relapsing-remitting MS
MSCoE Author(s): Cameron M
Int J MS Care. 2017 Jul-Aug;19(4):184-190. PMID: 28835742

Cannabinoids for treatment of MS symptoms: State of the evidence
MSCoE Author(s): Rice J*, Cameron M
Curr Neurol Neurosci Rep. 2018 Jun 19;18(8):50. PMID: 29923025

Longitudinal optical coherence tomography study of optic atrophy in secondary progressive MS: Results from a clinical trial cohort
MSCoE Author(s): Spain RI
Mult Scler. 2017 Nov 1:1352458517739136. PMID: 29111873

Methylphenidate is likely less effective than placebo for improving imbalance, walking, and fatigue in people with MS
MSCoE Author(s): Cameron MH
Mult Scler. 2017 Nov;23(13):1799-1801. PMID: 28165298

Moderators of treatment outcomes following telehealth self-management and education in adults with MS: A secondary analysis of a randomized controlled trial
MSCoE Author(s): Arewasikporn A*, Turner AP
Arch Phys Med Rehabil. 2018 Jul:99(7):1265-1272. PMID: 29337024

Phase 2 trial of ibudilast in progressive MS
MSCoE Author(s): Yadav V
N Engl J Med. 2018 Aug 30;379(9):846-855. PMID: 30157388

Sleep and its associations with perceived and objective cognitive impairment in individuals with MS
MSCoE Author(s): Haselkorn JK, Cameron MH, Turner AP
J Sleep Res. 2017 Aug;26(4):428-435. PMID: 28093823

Basic Science Research

MIF and D-DT are potential disease severity modifiers in male MS subjects
MSCoE Author(s): Offner H, Yadav V, Vandenbark AA
Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8421-E8429. PMID: 28923927

Epidemiology (Military Service)

The Gulf War era multiple sclerosis cohort: 3. Early clinical features
MSCoE Author(s): Wallin MT, Culpepper WJ, Maloni H
Acta Neurol Scand. 2018 Jan;137(1):76-84. PMID: 28832890

(*2017 - 2018 MS Fellow)

MSCoE MS Data Repository

The MS Centers of Excellence maintain a national MS Data Repository as a part of our mission. The MSCoE repository contains the VHA medial data of every patient diagnosed with MS since 1999; over 46,000 unique and de-identified cases. It is the largest collection of information on men with MS in the world. Men comprise more than 80% of the repository with an average age in the mid 50's. National Data Repository Data Map Image

Repository data has been used in our studies of exercise, smoking, obesity, pain, spasticity, falls, access to specialty care, disease modifying therapies, complementary and alternative medicine, telehealth, rural medicine, cost of care, and causes of death among VHA patients with MS. MSCoE also uses it to contact patients and caregivers who are within driving distance of upcoming MSCoE educational events, as well as for the delivery of our MS Veteran newsletter.

If you are interested in using the MS Data Repository, contact Steven.Leipertz@va.gov for details.


Disclaimer: Links are provided as a convenience and for informational purposes only. They do not constitute an endorsement or an approval by MSCoE of any of the products, services, or opinions of the organization. MSCoE bears no responsibility for the accuracy, legality, or content of the external site or for that of subsequent links. Contact the external site for answers to questions regarding its content.