Multiple Sclerosis Centers of Excellence Research and Development - Multiple Sclerosis Centers of Excellence
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Multiple Sclerosis Centers of Excellence


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Multiple Sclerosis Centers of Excellence Research and Development

The MS Centers of Excellence facilitate research to improve the understanding of MS among Veterans with MS. We advance forward the VA’s research mission by providing a structure and environment that facilitates MS laboratory, clinical, and epidemiologic and health services research. We also provide an environment for the incubation of ideas, and provide a structured network to advance research quickly. Our local and national multi-site trials enhance collaboration among VA medical facilities and increase the participation of Veterans in research activities. We also provide mentoring for VA Career Development Grants and National Institute of Health Awards.

MSCoE currently has over $18 million of research funding from various sources including the Veterans Affairs Rehabilitation Research and Development (VA RR&D) Service, National Institutes of Health (NIH), National Multiple Sclerosis Society (NMSS), and private industry. In addition, MSCoE conducts several unfunded research and scholarly activities. To learn about VA MS researchers and research, visit our VA MS Researchers page. To learn about VA MS fellows, visit our MSCoE Fellows page.

Clinical Research

A multicenter randomized controlled trial of two group education programs for fatigue in MS: Long-term (12-month) follow-up at one site
MSCoE Author(s): Hugos CL, Cameron MH
Mult Scler. 2019 May;25(6):871-875. PMID: 29761722

A multicenter randomized controlled trial of two group education programs for fatigue in MS: Short and medium-term benefits
MSCoE Author(s): Hugos C, Turner A, Haselkorn J, Cameron M
Mult Scler. 2019 Feb;25(2):275-285. PMID: 29226778

Anxiety is more important than depression in MS - No
MSCoE Author(s): Turner AP
Mult Scler. 2018 Apr;24(4):442-444. PMID: 29381113

Approaches to remyelination therapies in MS
MSCoE Author(s): Wooliscroft LW*, Silbermann EW*, Cameron MW
Curr Treat Options Neurol. 2019 Jun 28;21(7):34. PMID: 31250211

Cannabinoids for treatment of MS symptoms: State of the evidence
MSCoE Author(s): Rice J*, Cameron M
Curr Neurol Neurosci Rep. 2018 Jun 19;18(8):50. PMID: 29923025

Effect of high-intensity exercise on MS function and 31P MRS outcomes
MSCoE Author(s): Spain RIW
Med Sci Sports Exerc. 2019 Jul;51(7):1380-1386. PMID: 31205251

Longitudinal optical coherence tomography study of optic atrophy in secondary progressive MS: Results from a clinical trial cohort
MSCoE Author(s): Spain RIW
Mult Scler. 2019 Jan;25(1):55-62. PMID: 29111873

Methylphenidate is likely less effective than placebo for improving imbalance, walking, and fatigue in people with MS
MSCoE Author(s): Cameron MH
Mult Scler. 2017 Nov;23(13):1799-1801. PMID: 28165298

Moderators of treatment outcomes following telehealth self-management and education in adults with MS: A secondary analysis of a randomized controlled trial
MSCoE Author(s): Arewasikporn A*, Turner AP
Arch Phys Med Rehabil. 2018 Jul:99(7):1265-1272. PMID: 29337024

Telemedicine and MS: A comprehensive literature review
MSCoE Author(s): Maloni HE, Wallin MTE
J Telemed Telecare. 2019 May 1:1357633X19840097. PMID: 31042118 

Basic Science Research

MIF and D-DT are potential disease severity modifiers in male MS subjects
MSCoE Author(s): Offner H, Yadav V, Vandenbark AA
Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8421-E8429. PMID: 28923927

Epidemiology (Military Service)

A new way to estimate neurologic disease prevalence in the US: Illustrated with MS
MSCoE Author(s): Wallin MTE, Culpepper WJE
Neurology. 2019 Mar 5;92(10):469-480. PMID: 30770422

Global, regional, and national burden of MS 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016
MSCoE Author(s): Wallin MTE, Culpepper WJE
Lancet Neurol. 2019 Mar;18(3):269-285. PMID: 30679040

Global, regional, and national burden of neurological disorders, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016
MSCoE Author(s): Wallin MTE, Culpepper WJE
Lancet Neurol. 2019 May;18(5):459-480. PMID: 30879893

The prevalence of MS in the US: A population-based estimate using health claims data
MSCoE Author(s): Wallin MTE, Culpepper WJE
Neurology. 2019 Mar 5;92(10):e1029-e1040. PMID: 30770430

Validation of an algorithm for identifying MS cases in administrative health claims datasets
MSCoE Author(s): Culpepper WJE, Wallin MTE
Neurology. 2019 Mar 5;92(10):e1016-e1028. PMID: 30770432

* MSCoE Fellow

MSCoE MS Data Repository

The MS Centers of Excellence maintain a national MS Data Repository as a part of our mission. The MSCoE repository contains the VHA medial data of every patient diagnosed with MS since 1999; over 46,000 unique and de-identified cases. It is the largest collection of information on men with MS in the world. Men comprise more than 80% of the repository with an average age in the mid 50's. National Data Repository Data Map Image

Repository data has been used in our studies of exercise, smoking, obesity, pain, spasticity, falls, access to specialty care, disease modifying therapies, complementary and alternative medicine, telehealth, rural medicine, cost of care, and causes of death among VHA patients with MS. MSCoE also uses it to contact patients and caregivers who are within driving distance of upcoming MSCoE educational events, as well as for the delivery of our MS Veteran newsletter.

If you are interested in using the MS Data Repository, contact for details.

Disclaimer: Links are provided as a convenience and for informational purposes only. They do not constitute an endorsement or an approval by MSCoE of any of the products, services, or opinions of the organization. MSCoE bears no responsibility for the accuracy, legality, or content of the external site or for that of subsequent links. Contact the external site for answers to questions regarding its content.