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Research Advisory Committee on Gulf War Veterans' Illnesses


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Research Update - May 2007

The following journal articles were distributed for review in May 2007.  You can access the article's abstract by copying the paper title and pasting it into the search bar of the PubMed website, linked here. 

Research Relevant to Gulf War Service and Exposures
1. Occurrence of amyotrophic lateral sclerosis among Gulf War veterans.  (Armon C.  Neurology.  Mar 27, 2007; 68(13): 1083; author reply 1083)
2. Bioaccumulation, oxidative stress, and neurotoxicity in Danio rerio exposed to different isotopic compositions of uranium.  (Barillet S, et al.  Environ Toxicol Chem.  Mar 2007; 26(3): 497-505)
3. Zinc attenuates malathion-induced depressant-like behavior and confers neuroprotection in the rat brain.  (Brocardo PS, et al.  Toxicol Sci.  May 2007; 97(1): 140-148)
4. Development of miotic cross-tolerance between pyridostigmine and sarin vapor.  (Dabisch PA, et al.  J Ocul Pharmacol Ther.  Oct 2006; 22(5): 323-332)
5. Post-traumatic stress disorder and service utilization in a sample of service members for Iraq and Afghanistan.  (Erbes C, et al.  Mil Med.  Apr 2007; 172(4): 359-363)
6. JP-8 jet fuel can promote auditory impairment resulting form subsequent noise exposure in rats.  (Fechter LD, et al.  Toxicol Sci.  Mar 4, 2007; [Epub ahead of print])
 Butyrylcholinesterase and the control of synaptic responses in acetylcholinesterase knockout mice.  (Girard E, et al.  Life Sci.  Mar 28, 2007; [Epub ahead of print])
8. Quantitative magnetic resonance brain imaging in US Army veterans of the 1991 Gulf War potentially exposed to sarin and cyclosarin.  (Heaton KJ, et al.  Neurotoxicology.  Mar 24, 2007; [Epub ahead of print])
9. Health and exposure concerns of veterans deployed to Iraq and Afghanistan.  (Helmer DA, et al.  J Occup Environ Med.  May 2007; 49(5): 475-480)
10. Association of posttraumatic stress disorder with somatic symptoms, health care visits, and absenteeism among Iraq war veterans.  (Hoge CW, et al.  Am J Psychiatry  Jan 2007; 164(1): 150-153)
11. The interrelation between organophosphate toxicity and the epidemiology of depression and suicide.  (Jaga K, Dharmani C.  Rev Environ Health.  Jan-Mar 2007; 22(1): 57-73)
12. A normative value pilot study: levels of uranium in urine samples from UK civilians.  (Jones AD, et al.  Environ Res.  Apr 5, 2007; [Epub ahead of print])
13. Reproductive health of male Australian veterans of the 1991 Gulf War.  (Kelsall HL, et al.  BMC Public Health.  May 16, 2007; 7(1): 79 [Epub ahead of print])
14.¬†‚ÄúGulf War syndrome‚ÄĚ may be related to circadian dysrhythmia.¬† (LaDou J.¬† Int J Occup Environ Health.¬† Jan-Mar 2007; 13(1): 125-127)
15. Mortality among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study.  (Lee WJ, et al.  Environ Health Perspect.  Apr 2007; 115(4): 528-534.)
16. Delayed behavioral and endocrine effects of sarin and stress exposure in mice.  (Mach M, et al.  J Appl Toxicol.  May 14, 2007; [Epub ahead of print])
17. A comparative assessment of immunization records in the Defense Medical Surveillance system and the Vaccine Adverse Event Reporting System.  (McNeil MM, et al.  Vaccine.  Apr 30, 2007; 3428-3436)
18. Permethrin, but not deltamethrin, increases spontaneous glutamate release from hippocampal neurons in culture.  (Meyer DA, Shafer TJ.  Neurotoxicology.  Jul 2006; 27(4): 594-603)
19. A review of depleted uranium biological effects: in vitro and in vivo studies.  (Miller AC, McClain D.  Rev Environ Health.  Jan-Mar 2007; 22(1): 75-89)
20. Genetic susceptibility to environmental toxicants in ALS.  (Morahan JM, et al.  Am J Med Genet B Neuropsychiatr.  May 14, 2007 [Epub ahead of print])
21. Measurements of daily urinary uranium excretion in German peacekeeping personnel and residents of the Kosovo region to assess potential intakes of depleted uranium (DU).  (Oeh U, et al.  Sci Total Environ.  Apr 23, 2007; [Epub ahead of print])
22. Assessment of anthrax vaccine data in the Defense Medical Surveillance System, 1998-2004.  (Payne DC , et al.  Pharmacoepidemiol Drug Saf.  Apr 16, 2007; [Epub ahead of print])
23. Adverse reaction to anthrax vaccine (eg. optic neuritis) may be more complex or delayed than reported initially by Payne et al (2006).  (Schumm WR.  Arch Neurol.  Mar 2007; 64(3): 457-458; author reply 458)
24. Bringing the war back home: mental health disorders among 103,788 US veterans returning from Iraq and Afghanistan seen at Department of Veterans Affairs facilities.  (Seal KH, et al.  Arch Intern Med  Mar 12, 2007; 167(5): 476-482)
25. Neurotoxins and neurotoxicity mechanisms.  An overview.  (Segura-Aguilar J, Kostrzewa RM.   Neurotox Res.  Dec 2006; 10(3-4): 263-287)
26. Anthrax vaccination in the millennium cohort validation and measures of health.  (Smith B, et al.  Am J Prev Med.  Apr 2007; 32(4): 347-353)
27. Mental health of US Gulf War veterans 10 years after the war.  (Toomey R, et al.  Br J Psychiatry.   May 2007; 190: 385-393)
28. Risk and resilience factors for posttraumatic stress symptomatology in Gulf War I veterans.  (Vogt DS, Tanner LR.  J Trauma Stress  Feb 2007; 20(1); 27-38)
29. Particulate depleted uranium is cytotoxic and clastogenic to human lung cells.  (Wise SS, et al.  Chem Res Toxicol.  Apr 14, 2007; [Epub ahead of print])
Research on Evaluation/Treatment of Chronic Multisymptom Illnesses
1. Infection and vaccination in chronic fatigue syndrome: myth or reality?  (Appel S, Chapman J, Shoenfeld Y.  Autoimmunity.  Feb 2007; 40(1): 48-53)
2. Gabapentin in the treatment of fibromyalgia: a randomized, double-blind, placebo-controlled, multicenter trial.  (Arnold LM, et al.  Arthritis Rheum.  Mar 28, 2007; 56(4): 1336-1344 [Epub ahead of print])
3. An internet survey of 2,596 people with fibromyalgia.  (Bennett RM, et al.  BMC Musculoskelet Disord  Mar 9, 2007; 8: 27)
4. Fibromyalgia: update on mechanisms and management.  (Clauw DJ.  J Clin Rheumatol.  Apr 2007; 13(2): 102-109)
5. Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls.  (Cook DB, et al.  Neuroimage.  May 15, 2007; 56(3): 175-177)
6. Bronchial challenge testing to fragrance component as further diagnostic approach to non-immune immediate contact reactions.  (Harth V, et al.  Contact Dermatitis.  Mar 2007; 56(3): 175-177)
7. Is cognitive behaviour therapy for chronic fatigue syndrome also effective for pain symptoms?  (Knoop H, et al.  Behav Res Ther.  Mar 14, 2007; {Epub ahead of print])
8. The effect of cognitive behaviour therapy for chronic fatigue syndrome on self-reported cognitive impairments and neuropsychological test performance.  (Knoop H, et al.  J Neurol Neurosurg Psychiatry.  Apr 2007; 78(4): 434-436)
9. Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain?  (Kuchinad A, et al.  J Neurosci.  Apr 11, 2007; 27(15): 4004-4007)
10. Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants.  (Laske C, et al.  J Psychiatr Res.  Oct 2007; 41(7): 600-605)
11. Benefits of physical training in fibromyalgia and related syndromes.  (Maquet D, et al.  Ann Readapt Med Phys.  Apr 13, 2007; [Epub ahead of print])
12. A randomized, controlled, trial of controlled release paroxetine in fibromyalgia.  (Patkar AA, et al.  Am J Med.  May 2007; 120(5): 448-454)
13. The hypothalamo-pituitary-adrenal axis in chronic fatigue syndrome and fibromyalgia syndrome.  (Tanriverdi F, et al.  Stress.  Mar 2007; 10(1): 13-25)
14. Quality of life and capsaicin sensitivity in patients with airway symptoms induced by chemicals and scents: a longitudinal study.  (Ternesten-Hasseus E, Lowhagen O, Millqvist E.  Environ Health Perspect.  Mar 2007; 115(3): 425-429)