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Coming Off a Proton Pump Inhibitor


For patients who have made positive lifestyle changes and are less likely to need continued chronic acid suppression, it can still be difficult to come off PPIs. They often cause rebound hyperacidity, even if the underlying condition has resolved.[1] This occurs due to the lower stomach acidity increasing gastrin secretion, which causes the enterochromaffin cells to hypertrophy. When the PPI is suddenly discontinued, these larger cells have an increased capacity for acid secretion.[2] Figure 1 shows symptoms scores for dyspepsia in asymptomatic people given 40 milligrams of pantoprazole for 6 weeks versus controls. Despite being initially asymptomatic, they experienced rebound dyspepsia that lasted 10-14 days.[1]

Line graph showing the symptoms scores of dyspepsia. At week 7, after the cessation of therapy, there is sharp spike to the symptom score of 6 among the participants that took the Proton Pump Inhibitor. By week 8 the score is back down to 2.
Figure 1. Symptoms of reflux in people without GERD when taking PPIs versus placebo.1 Blue, dashed = Took PPI; Red, solid = Placebo group. Reprinted by permission from Macmillan Publishers LTD: American Journal of Gastroenterology, copyright 2010.

When counseling about discontinuing a PPI, let patients know that they will likely have symptoms of reflux for about 2 weeks after they stop the medication. Fortunately, there are strategies to help calm reflux symptoms until rebound hyperacidity resolves.

Bridge Therapy

The following therapies will not only increase success for discontinuing a PPI but also are therapeutic for gastroesophageal reflux disease (GERD).

  1. Focus on nutrition. Common foods that should be avoided in those with GERD include alcohol, caffeine (coffee), chocolate, cow’s milk, animal fat, and orange juice.
  2. Slowly taper off the PPI over 2-4 weeks (the higher the dose, the longer the taper).
  3. While the taper is being completed, use the following for bridge therapy to reduce the symptoms of rebound hyperacidity.
    • Encourage regular aerobic exercise.
    • Encourage a relaxation technique such as deep breathing. This enhances vagal stimulation, encouraging digestion, and aids adequate peristalsis. or more information, refer to “Power of the Mind” and “Mindful Awareness” Whole Health overviews.
    • Consider acupuncture 1-2 times per week.[3]
    • Add one or more of the following dietary supplements:
      • Deglycyrrhizinated licorice (DGL), 2-4 380 mg tablets before meals or sucralfate (Carafate) 1 gm before meals
      • Slippery elm, 1-2 tbsp of powdered root in water or 400-500 mg capsules or 5 mL of a tincture three to four times daily.
      • A combination botanical product, Iberogast 1 ml three times daily.[4]
  1. If the patient is successful with stopping the PPI, slowly taper off the above (except for positive nutritional changes, exercise, and stress management). If symptoms return, start again with one of the above or an H2 blocker (e.g., Ranitidine, 150 mg twice daily or as needed). If symptoms are still difficult to control, consider adding the PPI back at the lowest effective dose. Note: PPIs shut off all three acid pumps and H2 blockers are partial inhibitors of acid secretion. If long-term treatment is needed, H2 blockers allow better absorption of nutrients than PPIs and so potentially have fewer long-term adverse effects.
  2. For those with reflux hypersensitivity (those with normal endoscopies, normal pH monitoring/physiologic reflux, no esophageal motor disorder), consider an SSRI as first-line and an SNRI or tricylic anti-depressant as second-line. Patients with this condition are also more likely to have co-morbid behavioral disorders.[2]
  3. It would be most beneficial to avoid long-term acid suppression if possible since this is associated with malabsorption of vitamin B12[5] and iron,[6] increased risk of community-acquired pneumonia,[7] hip[8][9] and spine[10][11] fractures, diff diarrhea[6][12], and gastric cancer if a long-term PPI is used post H.pylori eradication therapy. [13] Early research has also suggested an association between chronic PPI use and dementia, which may be due to increases in amyloid plaque deposition.[14][15] Finally, PPIs have been associated with higher rates of acute interstitial nephritis and end-stage renal disease, so it may be prudent to wean off of them in patients at risk for chronic kidney disease progression.[15][16][17] For more details, refer to “Gastroesophageal Reflux Disease (GERD).”


“Coming Off a Proton Pump Inhibitor” was written by David Rakel, MD and updated by David Lessens, MD, MPH and Sagar Shah, MD. (2014, updated 2020). Sections were adapted from “Gastroesophageal Reflux Disease” by David Kiefer, MD, David Rakel, MD, and Rian Podein, MD.



  1. Niklasson A, Lindstrom L, Simren M, Lindberg G, Bjornsson E. Dyspeptic Symptom Development After Discontinuation of a Proton Pump Inhibitor: A Double-Blind Placebo-Controlled Trial. Am J Gastroenterol. 2010.
  2. Kim J, Blackett JW, Jodorkovsky D. Strategies for effective discontinuation of proton pump inhibitors. Curr Gastroenterol Rep. 2018;20(6):27.
  3. Dickman R, Schiff E, Holland A, et al. Clinical trial: acupuncture vs. doubling the proton pump inhibitor dose in refractory heartburn. Aliment Pharmacol Ther. 2007;26(10):1333-1344.
  4. Melzer J, Rosch W, Reichling J, Brignoli R, Saller R. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Aliment Pharmacol Ther. 2004;20(11-12):1279-1287.
  5. Lam JR, Schneider JL, Zhao W, Corley DA. Proton pumpinhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. Nat Med. 2013;310(22):2435-2442.
  6. Wilhelm SM, Rjater RG, Kale-Pradhan PB. Perils and pitfalls of long-term effects of proton pump inhibitors. Expert Rev Clin Pharmacol. 2013;6(4):443-451.
  7. Laheij RJ, Sturkenboom MC, Hassing RJ, Dieleman J, Stricker BH, Jansen JB. Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. JAMA. 2004;292(16):1955-1960.
  8. Corley DA, Kubo A, Zhao W, Quesenberry C. Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients. Gastroenterology. 2010;139(1):93-101.
  9. Gray SL, LaCroix AZ, Larson J, et al. Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the Women’s Health Initiative. Arch Intern Med. 2010;170(9):765-771.
  10. Kwok CS, Yeong JK, Loke YK. Meta-analysis: Risk of fractures with acid-suppressing medication. Bone. 2010.
  11. Insogna KL. The effectof proton pump-inhibiting drugs on mineral metabolism. Am J Gastroenterol. 2009;104:S2-S4.
  12. Cunningham R, Dale B, Undy B, Gaunt N. Proton pump inhibitors as a risk factor for Clostridium difficile diarrhoea. J Hosp Infect. 2003;54(3):243-245.
  13. Tan MC, Graham DY. Proton pump inhibitor therapy after Helicobacter pylori eradication may increase the risk of gastric cancer. BMJ Evid Based Med. 2018;23(3):111-112.
  14. Gomm W, von Holt K, Thomé F, et al. Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis. JAMA Neurol. 2016;73(4):410-416.
  15. Klepser DG, Collier DS, Cochran GL. Proton pump inhibitors and acute kidney injury: a nested case-control study. BMC Nephrol. 2013;14:150.
  16. Antoniou T, Macdonald EM, Hollands S, et al. Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study. CMAJ open. 2015;3(2):E166-171.
  17. Lazarus B, Chen Y, Wilson FP, et al. Proton pump inhibitor use and the risk of chronic kidney disease. JAMA Intern Med. 2016;176(2):238-246.