Geriatric Research Education and Clinical Center (GRECC)
Eastern Colorado GRECC Team
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Kerrie L. Moreau, PhD
Title: Principal Investigator; Professor, CU Division of Geriatrics
Contact: kerrie.moreau@cuanschutz.edu
University of Colorado webpage
Personal Statement
I have been conducting clinical research studies focusing on sex hormones, exercise and cardiovascular aging for 20 years. My laboratory investigates the mechanisms underlying vascular protection of gonadal hormones, including how declines in ovarian function during the menopause transition, and low testosterone in aging men, contributes to an acceleration in cardiovascular aging, as characterized by endothelial dysfunction, arterial stiffening. intimal-medial thickening and cardiac dysfunction. As an exercise physiologist, we also investigate the modulatory influence of sex hormones on cardiovascular adaptations to habitual exercise. My laboratory uses a variety of experimental techniques and skills to study the integrative biology of the aging vasculature in humans, which has allowed me to develop a successful clinical research program to study the mechanisms underlying sex hormone deficiency and vascular aging in humans.
Research Interest
Research Interest
My translational research approach includes ultrasound imaging to examine the arteries and heart, gonadal suppression interventions to isolate the role of sex hormones, infusion models to isolate the influence of oxidative stress, and endothelial cell harvests from peripheral veins and arteries to determine cellular mechanisms. I am currently the PI on an NIH R01 award investigating the cardiovascular consequences of low testosterone in older men and its contributions to Alzheimer’s Disease risk and its related dementias in middle-aged and older men. Additionally, I am the Director of the Cardiovascular BioImaging Core at the University of Colorado Denver Anschutz Medical Campus which is a dedicated research facility for protocols utilizing cardiovascular imaging. In summary, I have demonstrated a productive record in carrying out clinical research studies that impact public health.
Dimensions profile: See publications, grant, datasets, patents and clinical trial information.
The following images visualize Dr. Moreau's work. The word cloud is drawn from publication titles. The research collaboration map shows research relationships (click the image to enlarge):
| Publications | Grants |
|---|---|
| Clinical Research | Aging |
| Aging | Clinical Research |
| Cardiovascular | Cardiovascular |
| Prevention | Prevention |
| Contraception/Reproduction | Estrogen |
| Estrogen | Contraception/Reproduction |
| Clinical Trials and Supportive Activities | Heart Disease |
| Heart Disease | Clinical Trials and Supportive Activities |
| Nutrition | Neurosciences |
| Lung | Bioengineering |
Grants & Funding
Cardiovascular Consequences of Hypogonadism in Men
The findings from this research should provide new information into whether declines in testosterone cause blood vessels and the heart in middle-aged and older men to become unhealthy. Moreover, determining the possible causes of cardiovascular health changes related to declines in testosterone may lead to the development of preventive and therapeutic strategies that favorably modify these factors and prevent or slow changes in vascular and cardiac health and decrease cardiovascular disease risk.
Investigator: Kerrie Moreau
Funder: National Institute on Aging
NIH website
Publications of note:
— Assessment of macrovascular and microvascular function in aging males
— Body composition and cardiometabolic health across the menopause transition
— Sex Differences in Peripheral Artery Disease
MitoQ supplementation for restoring aerobic exercise training effects on endothelial function in postmenopausal women
Regular exercise is associated with a reduced cardiovascular disease (CVD) risk. It is a therapeutic intervention for improving vascular health. Although regular aerobic exercise improves vascular health in older men, it has not consistently improved vascular health in older women.
The proposed studies will test the efficacy of administering a mitochondrial-targeted antioxidant (MitoQ) for restoring exercise training benefits on endothelial function in estrogen-deficient postmenopausal women.
Investigator: Kerrie Moreau
Funder: National Institute on Aging
NIH website
Integrative Physiology of Aging Training Grant
This Integrative Physiology of Aging T32 will train the next generation of clinicians and physiologists to understand better and investigate the specific needs/concerns of an aging population.
This T32 emphasizes:
1. Co- mentoring of trainees by Primary and Secondary mentors.
2. Carefully constructed career development plans.
3. Exposure to leadership and “team training” skills to maximize future scientific impact.
Investigator: Kerrie Moreau
Funder: National Institute on Aging
NIH website
Publications of note:
— Stakeholder and Data Driven Fall Screen in a Program of All-Inclusive Care for the Elderly: Quality Improvement Initiative
— Oxidative Stress and Inflammation Are Associated With Age-Related Endothelial Dysfunction in Men With Low Testosterone
— Utilization of Mid-Thigh Magnetic Resonance Imaging to Predict Lean Body Mass and Knee Extensor Strength in Obese Adults
Recent Publications
2023
Longtine AG, Venkatasubramanian R, Zigler MC, Lindquist AJ, Mahoney SA, Greenberg NT, VanDongen NS, Ludwig KR, Moreau KL, Seals DR, Clayton ZS. Female C57BL/6N mice are a viable model of aortic aging in women. Am J Physiol Heart Circ Physiol. 2023 Apr 28. doi: 10.1152/ajpheart.00120.2023. Epub ahead of print.
PMID: 37115626.
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Iwamoto SJ, Defreyne J, Kaoutzanis C, Davies RD, Moreau KL, Rothman MS. Gender-affirming hormone therapy, mental health, and surgical considerations for aging transgender and gender diverse adults. Ther Adv Endocrinol Metab. 2023 Apr 19;14:20420188231166494. doi: 10.1177/20420188231166494. PMCID: PMC10126651.
PMID: 37113210.
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Oneglia AP, Szczepaniak LS, Jaffery MF, Cipher DJ, McDonald JG, Haykowsky MJ, Moreau KL, Clegg DJ, Zaha V, Nelson MD. Myocardial steatosis impairs left ventricular diastolic-systolic coupling in healthy humans. J Physiol. 2023 Mar 8. doi: 10.1113/JP284272. Epub ahead of print.
PMID: 36891609.
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2022
Erickson ML, Allen JM, Beavers DP, Collins LM, Davidson KW, Erickson KI, Esser KA, Hesselink MKC, Moreau KL, Laber EB, Peterson CA, Peterson CM, Reusch JE, Thyfault JP, Youngstedt SD, Zierath JR, Goodpaster BH, LeBrasseur NK, Buford TW, Sparks LM. Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary. Geroscience. 2022 Oct 15. doi: 10.1007/s11357-022-00668-3. Epub ahead of print.
PMID: 36242693.
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DuBose LE, Ozemek C, Wick T, Richardson V, Hildreth KL, Moreau KL. Role of BH4 Deficiency as a Mediator of Oxidative Stress-Related Endothelial Dysfunction in Menopausal Women. Am J Physiol Heart Circ Physiol. 2022 Sep 23. doi: 10.1152/ajpheart.00435.2022. Epub ahead of print.
PMID: 36149770.
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Kuczmarski AV, Welti LM, Moreau KL, Wenner MM. ET-1 as a Sex-Specific Mechanism Impacting Age-Related Changes in Vascular Function. Front Aging. 2021 Aug 31;2:727416. doi: 10.3389/fragi.2021.727416. PMCID: PMC9261354.
PMID: 35822003.
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Babcock MC, DuBose LE, Hildreth KL, Stauffer BL, Cornwell WK 3rd, Kohrt WM, Moreau KL. Age-associated reductions in cardiovagal baroreflex sensitivity are exaggerated in middle-aged and older men with low testosterone. J Appl Physiol (1985). 2022 Jun 30. doi: 10.1152/japplphysiol.00245.2022. Epub ahead of print.
PMID: 35771224.
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Pabon M, Cheng S, Altin SE, Sethi SS, Nelson MD, Moreau KL, Hamburg N, Hess CN. Sex Differences in Peripheral Artery Disease. Circ Res. 2022 Feb 18;130(4):496-511. doi: 10.1161/CIRCRESAHA.121.320702. Epub 2022 Feb 17.
PMID: 35175843.
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2021
Marlatt KL, Pitynski-Miller DR, Gavin KM, Moreau KL, Melanson EL, Santoro N, Kohrt WM. Body composition and cardiometabolic health across the menopause transition. Obesity (Silver Spring). 2022 Jan;30(1):14-27. doi: 10.1002/oby.23289.
PMID: 34932890.
Find more information on this paper from the Dimensions website
Babcock MC, DuBose LE, Witten TL, Stauffer BL, Hildreth KL, Schwartz RS, Kohrt WM, Moreau KL. Oxidative stress and inflammation are associated with age-related endothelial dysfunction in men with low testosterone. J Clin Endocrinol Metab. 2021 Oct 1:dgab715. doi: 10.1210/clinem/dgab715. Epub ahead of print.
PMID: 34597384
Streed CG Jr, Beach LB, Caceres BA, Dowshen NL, Moreau KL, Mukherjee M, Poteat T, Radix A, Reisner SL, Singh V; American Heart Association Council on Peripheral Vascular Disease; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Stroke Council. Assessing and Addressing Cardiovascular Health in People Who Are Transgender and Gender Diverse: A Scientific Statement From the American Heart Association. Circulation. 2021 Jul 8:CIR0000000000001003. doi: 10.1161/CIR.0000000000001003. Epub ahead of print.
PMID: 34235936
Luehrs RE, Moreau KL, Pierce GL, Wamboldt F, Aloia M, Weinberger HD, Make B, Bowler RP, Crapo JD, Meschede K, Kozora E, Moser DJ, Hoth KF. Cognitive Performance is Lower Among Individuals with Overlap Syndrome than with COPD or Obstructive Sleep Apnea Alone: Role of Carotid Artery Stiffness. J Appl Physiol (1985). 2021 May 13. doi: 10.1152/japplphysiol.00477.2020. Epub ahead of print.
PMID: 33982592
Nokoff NJ, Scarbro SL, Moreau KL, Zeitler P, Nadeau KJ, Reirden D, Juarez-Colunga E, Kelsey MM. Body Composition and Markers of Cardiometabolic Health in Transgender Youth on Gonadotropin-Releasing Hormone Agonists. Transgend Health. 2021 Apr 16;6(2):111-119. doi: 10.1089/trgh.2020.0029. PMCID: PMC8080916.
PMID: 33937527
Park YM, Jankowski CM, Swanson CM, Hildreth KL, Kohrt WM, Moreau KL. Bone Mineral Density in Different Menopause Stages is Associated with Follicle Stimulating Hormone Levels in Healthy Women. Int J Environ Res Public Health. 2021 Jan 29;18(3):1200. doi: 10.3390/ijerph18031200.
PMID: 33572819
