Geriatric Research Education and Clinical Center (GRECC)

Salt Lake City GRECC

• Blood pressure, blood flow, and metabolic regulation in both aging and disease
• Cellular mechanisms of vascular aging and atherosclerosis
• Neuroinflammation and brain metabolism with aging
• Decision support tools and collection of data for surveillance, analysis, and program evaluation

• Passive limb movement: a tool to assess vascular health and guide rehabilitation
• Targeting oxidative stress to prevent vascular and skeletal muscle dysfunction during disuse
• Efficacy of exercise training in patients with heart failure with preserved ejection fraction
• Novel approaches for improving vascular function in Veterans with heart failure with preserved ejection fraction
• Vascular endothelial function: a potential therapeutic target in Alzheimer’s disease
• Premature fatigue in patients with heart failure: neuronal influences
• Nicotine effects on host inflammation
• Mechanisms of augmented atherosclerotic progression with aging
• Amelioration of aged endothelial dysfunction by nampt and caloric restriction
• Telomere uncapping and arterial dysfunction
• Platelet reprogramming during inflammation
• The role of dacilzumab or disease through interaction with oligodendrocyte
• Pragmatic evaluation of events and benefits of lipid-lowering in older adults (PREVENTABLE) clinical trial site

• Interprofessional training in that cultivates future geriatrics leaders (Advanced Geriatrics Fellowship and T32 training programs)
• Regular host of the Rocky Mountain Geriatrics Conference for attendees nationwide on key geriatrics topics
• A resource locally and nationally for staff and associated health trainee continuing education
• Collaboration with the Utah Geriatrics Workforce Enhancement Program

• Dementia telemedicine initiatives for Veterans and their caregivers, especially in the rural, Intermountain West
• Coordination of benefits with community agencies such as Area Agencies on Aging and home health agencies
• Operational initiatives that train providers to promote completion of advance planning of life sustaining treatment
• Improving access for highly rural Veterans
• Leveraging informatics data resources to inform geriatric clinical care
• Exercise promotion and support for older adults
• Care Transitions from Hospital to SNF, including use of PharmD as well as RN led teams
• Improving care for older adult surgical patients through use of a Geriatric Surgery Interdisciplinary Team

• Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial JAMA https://pubmed.ncbi.nlm.nih.gov/30688979/
• Association of Intensive vs Standard Blood Pressure Control With Cerebral White Matter Lesions JAMA https://pubmed.ncbi.nlm.nih.gov/31408137/
• Strong Relationship Between Vascular Function in the Coronary and Brachial Arteries Hypertension https://pubmed.ncbi.nlm.nih.gov/31055952/
• Veterans Caregiving for Others: Caregiving as a Factor in the Health of America's Military Veterans Mil Med https://pubmed.ncbi.nlm.nih.gov/29901741/
• Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress J Mol Cell Cardiol https://pubmed.ncbi.nlm.nih.gov/30502348/

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