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Geriatric Research Education and Clinical Center (GRECC)

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San Antonio GRECC

San Antonio GRECC

South Texas Veterans Health Care System (STVHCS)
Audie L. Murphy VA Medical Center
7400 Merton Minter Boulevard
San Antonio, Texas 78229-4404

Tel. 210-617-5300 x16044
Fax 210-617-5312

GRECC Director (Acting)

Chih-Ko Yeh, MD

Associate Director, Research

Vacant

Associate Director, Clinical

Vacant

Associate Director, Education and Evaluation (Acting)

Brande Harris, DO, FACP

Administrative Officer

Donald Allbright
Donald.Allbright@va.gov

research foci heading
  • Geroscience approach to accelerate new findings in basic aging biology from the bench to the patient’s bedside
  • Lifestyle interventions, including exercise, to improve physical and metabolic health in older adults
  • Trials of age-modulating agents in older adults to improve physical function, frailty, biologic resilience, sarcopenic obesity, immune function, cardiovascular health and cognition
  • Mechanistic trials of thermoregulatory sequelae of chronic spinal cord injury with emphasis on altered vasomotor control mechanisms
  • Molecular mechanisms underlying the role of nutrient sensors in obesity and diabetes
  • The metabolic aspects and molecular pathogenesis of alcoholic liver disease and identifying novel therapeutic targets for its treatment
  • Hepatokine regulation of nutrient metabolism, energy homeostasis and fatty liver disease related to aging
research heading
  • Innovative health care models to ameliorate frailty and optimize quality of life
  • Promotion of successful weight management in older adults with overweight/obesity and Type 2 diabetes
  • Mechanism of microbiome-induced insulin resistance in humans
  • Effects of mTOR inhibition and rapamycin on physical function, immune function, cardiovascular function, cognition, malignancy and COVID-19
  • Functional role of mTOR in hepatic insulin resistance
  • Pilot trial of topical rapamycin’s effects on keloid regression
  • Efficacy and safety of rapamycin in early Alzheimer’s disease
  • FGF21 as a novel modulator of metabolism in age-related metabolic disease
  • Role of SIRT1 and AMP-activated protein kinase in liver aging and age-related Non-Alcoholic Steatohepatitis (NASH) and metabolic disease
  • Role of TLR4 on insulin resistance in humans
  • Aspirin in Reducing Events in the Elderly (ASPREE and ASPREE-XT)
  • Clinical trial of metformin for frailty prevention in older adults with insulin resistance
  • Pragmatic Evaluation of Events and Benefits of Lipid-Lowering in Older Adults (PREVENTABLE)
  • Diabetes Prevention Program Outcomes Study (DPPOS)
  • Cellular resilience as a predictor of healthy aging
  • South Texas Aging Registry and Repository
  • The effects of nicotinamide adenine dinucleotide (NAD) on brain function and cognition
  • The physiologic effects of intranasal oxytocin on sarcopenic obesity
  • Clinical trials of senolytic agents for idiopathic pulmonary fibrosis, cognitive impairment/dementia and COVID-19
  • Metformin to improve vaccine response and prolong healthspan in older adults
education heading
  • Interprofessional training focused on the 5Ms of geriatrics and palliative care in academic and clinical settings
  • Development of our future leaders in medical education and aging research
  • Dissemination of existing knowledge and new developments in the fields of aging and palliative care to local and national trainees
  • Serve as a local and national resource for interprofessional staff development in the areas of aging and palliative care
  • Dementia caregiver support and education program
clinical heading
  • Gerofit - supervised exercise and health program designed for older Veterans enrolled at VA
  • Former Prisoner of War Clinic - implementing innovative telemedicine-based assessment of FPOWs by an interdisciplinary team to identify previously unrecognized FPOW presumptive service-connected and other disabilities
  • Geriatrics Medicine Education at Discharge (GMED) - transitional care program for vulnerable older Veterans to reduce 30 -day readmissions and reduce polypharmacy
  • Virtual Geriatrics - consultation for frail Veterans, focusing on rural Veterans, to increase access to care via telehealth modalities
  • Life sustaining treatment decisions Initiative
  • Implementation of patient priorities care in geriatrics services, which helps patients and providers focus decision making and health care on what matters most to patients
publications heading