San Antonio GRECC - Geriatric Research Education and Clinical Center (GRECC)
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Geriatric Research Education and Clinical Center (GRECC)

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San Antonio GRECC

research foci heading
  • Geroscience approach to accelerate new findings in basic aging biology from the bench to the patient’s bedside
  • Lifestyle interventions, including exercise, to improve physical and metabolic health in older adults
  • Trials of age-modulating agents in older adults to improve physical function, frailty, biologic resilience, sarcopenic obesity, immune function, cardiovascular health and cognition
  • Mechanistic trials of thermoregulatory sequelae of chronic spinal cord injury with emphasis on altered vasomotor control mechanisms
  • Molecular mechanisms underlying the role of nutrient sensors in obesity and diabetes
  • The metabolic aspects and molecular pathogenesis of alcoholic liver disease and identifying novel therapeutic targets for its treatment
  • Hepatokine regulation of nutrient metabolism, energy homeostasis and fatty liver disease related to aging
research heading
  • Innovative health care models to ameliorate frailty and optimize quality of life
  • Promotion of successful weight management in older adults with overweight/obesity and Type 2 diabetes
  • Mechanism of microbiome-induced insulin resistance in humans
  • Effects of mTOR inhibition and rapamycin on physical function, immune function, cardiovascular function, cognition, malignancy and COVID-19
  • Functional role of mTOR in hepatic insulin resistance
  • Pilot trial of topical rapamycin’s effects on keloid regression
  • Efficacy and safety of rapamycin in early Alzheimer’s disease
  • FGF21 as a novel modulator of metabolism in age-related metabolic disease
  • Role of SIRT1 and AMP-activated protein kinase in liver aging and age-related Non-Alcoholic Steatohepatitis (NASH) and metabolic disease
  • Role of TLR4 on insulin resistance in humans
  • Aspirin in Reducing Events in the Elderly (ASPREE and ASPREE-XT)
  • Clinical trial of metformin for frailty prevention in older adults with insulin resistance
  • Pragmatic Evaluation of Events and Benefits of Lipid-Lowering in Older Adults (PREVENTABLE)
  • Diabetes Prevention Program Outcomes Study (DPPOS)
  • Cellular resilience as a predictor of healthy aging
  • South Texas Aging Registry and Repository
  • The effects of nicotinamide adenine dinucleotide (NAD) on brain function and cognition
  • The physiologic effects of intranasal oxytocin on sarcopenic obesity
  • Clinical trials of senolytic agents for idiopathic pulmonary fibrosis, cognitive impairment/dementia and COVID-19
  • Metformin to improve vaccine response and prolong healthspan in older adults
education heading
  • Interprofessional training focused on the 5Ms of geriatrics and palliative care in academic and clinical settings
  • Development of our future leaders in medical education and aging research
  • Dissemination of existing knowledge and new developments in the fields of aging and palliative care to local and national trainees
  • Serve as a local and national resource for interprofessional staff development in the areas of aging and palliative care
  • Dementia caregiver support and education program
clinical heading
  • Gerofit - supervised exercise and health program designed for older Veterans enrolled at VA
  • Former Prisoner of War Clinic - implementing innovative telemedicine-based assessment of FPOWs by an interdisciplinary team to identify previously unrecognized FPOW presumptive service-connected and other disabilities
  • Geriatrics Medicine Education at Discharge (GMED) - transitional care program for vulnerable older Veterans to reduce 30 -day readmissions and reduce polypharmacy
  • Virtual Geriatrics - consultation for frail Veterans, focusing on rural Veterans, to increase access to care via telehealth modalities
  • Life sustaining treatment decisions Initiative
  • Implementation of patient priorities care in geriatrics services, which helps patients and providers focus decision making and health care on what matters most to patients
publications heading

Tau protein aggregation is associated with cellular senescence in the brain Aging Cell https://pubmed.ncbi.nlm.nih.gov/30126037/

Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets Am J Primatol https://pubmed.ncbi.nlm.nih.gov/30311681/

Rapamycin and Alzheimer's disease: Time for a clinical trial? Sci Transl Med https://pubmed.ncbi.nlm.nih.gov/30674654/

Review of Interventions for the Frailty Syndrome and the Role of Metformin as a Potential Pharmacologic Agent for Frailty Prevention Clin Ther https://pubmed.ncbi.nlm.nih.gov/30851950/

NFκB Regulates Muscle Development and Mitochondrial Function J Gerentol A Biol Sci Med Sci https://pubmed.ncbi.nlm.nih.gov/30423026/

San Antonio GRECC

South Texas Veterans Health Care System (STVHCS)
Audie L. Murphy VA Medical Center
7400 Merton Minter Boulevard
San Antonio, Texas 78229-4404

Phone 210-617-5300 ext. 16044
Fax     210-617-5312

Affiliations

University of Health San Antonio

GRECC Director

Sara E. Espinoza, MD

Associate Director, Research

Nicolas Musi, MD

Associate Director, Education and Evaluation (Acting)

Becky Powers, MD

Associate Director, Clinical

VACANT

Administrative Officer

Sheva J. Allen, MHA
Sheva.Allen@va.gov