Puget Sound GRECC - Geriatric Research Education and Clinical Center (GRECC)
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Geriatric Research Education and Clinical Center (GRECC)

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Puget Sound GRECC

research foci heading
  • Aging, genetics, and environmental factors in neurodegeneration and dementia
  • Brain pharmacodynamics and drug transport in normative aging, injury, and dementia
  • Endocrinology relating aging, body composition, and cancer
research heading
  • Genetic dissection of catecholaminergic innervation of the cognitive cerebellum
  • Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related cachexia
  • Understanding how DOPA decarboxylase modulates tau in disease
  • Inhibiting pathological TDP-43 phosphorylation as a therapeutic strategy for ALS
  • AirpPollution, the aging brain and Alzheimer's disease
  • Approach to the aberrant androgen receptor signaling in lethal prostate cancer
  • Neural mechanisms of impulsivity and attention following TBI
  • The role of APOE locus genes regulation in Alzheimer’s disease
  • Genetic movement disorders: etiologies and pathogeneses
  • Intranasal insulin in a mouse model of Alzheimer’s disease
education heading
  • Support of Northwest Geriatrics Education Center lecture series (which spans across the VISN)
  • Leadership on VISN and national education committees, and in implementing education elements of VA Dementia System of Care Directive
  • Practicum site for Geriatric Scholars program, which enhances geriatric education in rural facilities
  • Training site for psychiatry and medicine fellows, residents and medical students
  • Support of trainees in optometry, social work, psychology, and audiology/speech pathology
clinical heading
  • Falls screening and intervention programs for Veterans at high risk of injury
  • Telemedicine, Adherence, and Geriatric Veterans (TAG Vets): improving medication compliance using mobile technology
  • Patient Priorities Care (PPC) in CLCs
  • Dementia Immersion Simulation Experience (DISE)
  • Healthy Aging Project – Brain (HAP-B)
  • Veteran Increased Access to neuropsychological services via Telehealth (VIA TeleNP)
publications heading

Glia-specific APOE epigenetic changes in the Alzheimer's disease brain Brain Res https://pubmed.ncbi.nlm.nih.gov/30081037/

Detection of probable dementia cases in undiagnosed patients using structured and unstructured electronic health records BMC Med Inform Dec Mak https://pubmed.ncbi.nlm.nih.gov/31288818/

Paclitaxel Reduces Brain Injury from Repeated Head Trauma in Mice J Alzheimers Dis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043206/

Effect of testosterone replacement on measures of mobility in older men with mobility limitation and low testosterone concentrations: secondary analyses of the Testosterone Trials Lancet Diabetes Endocrinolhttps://pubmed.ncbi.nlm.nih.gov/30366567/

Assessing Cachexia Acutely after Autologous Stem Cell Transplant Cancers (Basel) https://pubmed.ncbi.nlm.nih.gov/31487803/

Puget Sound GRECC

VA Puget Sound Healthcare System
1660 South Columbian Way
Seattle, WA 98108

Phone  206-764-2842
Fax      206-764-2569

Affiliations

University of Washington

GRECC Director

Debby Tsuang, MD, MSc

Associate Director, Research

Brian Kraemer, PhD

Associate Director, Education and Evaluation

Stephen Thielke, MD, MS, MA

Associate Director, Clinical

Katherine Ritchey, DO, MPH

Administrative Officer

Elizabeth Aigbe
Elizabeth.Aigbe@va.gov