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VA » Health Care » Geriatric Research Education and Clinical Center (GRECC) » Eastern Colorado GRECC Team

Geriatric Research Education and Clinical Center (GRECC)

Eastern Colorado GRECC Team

Investigators & Team Home | Research Interests | Publications | Grants/Awards

Christine Swanson, MD, MCR

Title: EC GRECC Investigator; Associate Professor, Medicine-Endocrinology/Metabolism/Diabetes, Ludeman Family Center for Women's Health Research

University of Colorado webpage

An inadequate amount of poorly timed (daytime) sleep can impair optimal health and are risk factors for metabolic conditions like diabetes and obesity. We were the first to report that an altered sleep schedule (similar to the stresses experienced during rotating shift work) could negatively impact bone health in men by decreasing a marker of bone formation. Over time, less bone formed could lead to bone loss, osteoporosis, and a higher risk of fracture. Women are more commonly affected by osteoporosis than men, however, the effects of altered sleep timing and duration on bone health in women are unknown. This research, made possible by the Ludeman Family Center for Women's Health Research, will investigate if the same altered sleep schedule negatively impacts bone health in women, as it does in men. If sleep disruption negatively impacts bone metabolism it could impact women’s health by altering the approach to the prevention, evaluation and treatment of osteoporosis.

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Research Interest

See Dr. Swanson's Dimensions profile that includes: publications, grants, datasets, patents and clinical trials.

Research Interest
Evidence-based exercise interventions for Veterans with knee osteoarthritis
Non-pharmacological interventions for managing chronic diseases (specifically arthritis) in older adults

The following images visualize Dr. Swanson's work. The word cloud is drawn from publication titles. The research collaboration map shows research relationships (click the image to enlarge):

Dr. Swanson's publication titles indicate her primary work is strengthening bones — Word cloud from pub titles

Dr. Swanson's collaborations are primarily from the University of Colorado — Research collaboration map

The following research fields have been used to summarize Dr. Swanson's publications and grants.
Publications	Grants
Sleep Research	Aging
Aging	Osteoporosis
Clinical Research	Sleep Research
Prevention	Prevention
Osteoporosis	Clinical Research
Neurosciences	Neurosciences
Cardiovascular	Clinical Trials and Supportive Activities
Nutrition
Contraception/Reproduction
Estrogen

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Recent Publications

2023

Swanson CM, Krohn K, Wiseman A, Rothman MS. New Human Leukocyte Antigen (HLA) Antibody Formation and Creatinine Elevation With Abaloparatide in Kidney Transplant Recipient. JBMR Plus. 2023 Sep 21;7(12):e10814. doi: 10.1002/jbm4.10814. PMCID: PMC10731105.
PMID: 38130769.
Learn more about this publication on Dimensions

Armento A, Heronemus M, Truong D, Swanson C. Bone Health in Young Athletes: a Narrative Review of the Recent Literature. Curr Osteoporos Rep. 2023 Aug;21(4):447-458. doi: 10.1007/s11914-023-00796-5. Epub 2023 Jun 8. PMCID: PMC10248337.
PMID: 37289381.
Learn more about this publication on Dimensions

2022

Sabri SA, Chavarria JC, Ackert-Bicknell C, Swanson C, Burger E. Osteoporosis: An Update on Screening, Diagnosis, Evaluation, and Treatment. Orthopedics. 2023 Jan-Feb;46(1):e20-e26. doi: 10.3928/01477447-20220719-03. Epub 2022 Jul 25. PMCID: PMC10084730.
PMID: 35876780.
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Swanson C. Sleep Disruption and Bone Health. Curr Osteoporos Rep. 2022 Jun;20(3):202-212. doi: 10.1007/s11914-022-00733-y. Epub 2022 Apr 30.
PMID: 35488985.
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Swanson CM, Shanbhag P, Tussey EJ, Rynders CA, Wright KP Jr, Kohrt WM. Bone Turnover Markers After Six Nights of Insufficient Sleep and Subsequent Recovery Sleep in Healthy Men. Calcif Tissue Int. 2022 Feb 8. doi: 10.1007/s00223-022-00950-8. Epub ahead of print.
PMID: 35133471.
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2021

Wherry SJ, Swanson CM, Kohrt WM. Acute catabolic bone metabolism response to exercise in young and older adults: A narrative review. Exp Gerontol. 2021 Nov 23:111633. doi: 10.1016/j.exger.2021.111633. Epub ahead of print.
PMID: 34826573.
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Wherry SJ, Blatchford PJ, Swanson CM, Wellington T, Boxer RS, Kohrt WM. Maintaining Serum Ionized Calcium during Brisk Walking Attenuates the Increase in Bone Resorption in Older Adults. Bone. 2021 Jul 9:116108. doi: 10.1016/j.bone.2021.116108. Epub ahead of print.
PMID: 34252605.
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Depner CM, Rice JD, Tussey EJ, Eckel RH, Bergman BC, Higgins JA, Melanson EL, Kohrt WM, Wright K Jr, Swanson CM. Bone turnover marker responses to sleep restriction and weekend recovery sleep. Bone. 2021 Jun 30:116096. doi: 10.1016/j.bone.2021.116096. Epub ahead of print.
PMID: 34216838.
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Swanson CM. Sleep disruptions and bone health: what do we know so far? Curr Opin Endocrinol Diabetes Obes. 2021 Aug 1;28(4):348-353. doi: 10.1097/MED.0000000000000639. PMCID: PMC8244577.
PMID: 33965968.
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Park YM, Jankowski CM, Swanson CM, Hildreth KL, Kohrt WM, Moreau KL. Bone Mineral Density in Different Menopause Stages is Associated with Follicle Stimulating Hormone Levels in Healthy Women. Int J Environ Res Public Health. 2021 Jan 29;18(3):1200. doi: 10.3390/ijerph18031200.
PMID: 33572819.
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Sailer C, Edelmann H, Buchanan C, Giro P, Babcock M, Swanson C, Spotts M, Schulte M, Pratt-Cordova A, Coe G, Beindorff M, Page RL 2nd, Ambardekar AV, Pal JD, Kohrt W, Wolfel E, Lawley JS, Tarumi T, Cornwell WK 3rd. Impairments in Blood Pressure Regulation and Cardiac Baroreceptor Sensitivity Among Patients With Heart Failure Supported With Continuous-Flow Left Ventricular Assist Devices. Circ Heart Fail. 2021 Jan;14(1):e007448. doi: 10.1161/CIRCHEARTFAILURE.120.007448. Epub 2021 Jan 19. PMCID: PMC7818348.
PMID: 33464953.
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Grants & Funding

Fractured Schedules: Skeletal Effects of Acute and Chronic Night Shift Work: Grant number: R01HL151332; Funding amount: $711,761.00; Start/End date: 7/1/2021 - 6/30/2026; Public Health Relevance Statement
Our work has shown that humans exposed to several weeks of recurring 28-hour days to induce sleep restriction and circadian disruption (e.g., shift work, jet lag) had significantly decreased bone formation, with no change or an increase in bone resorption - an imbalance that could lead to bone loss, osteoporosis, and increased fracture risk. This R01 proposal will investigate the acute and chronic effects of real-world night shift work schedules on bone metabolism, density, quality and strength, and evaluate system-level mechanisms, including increased sympathetic tone. Results will inform screening recommendations for night shift workers, and introduce a paradigm shift in the prevention, evaluation, and treatment of osteoporosis.; Funder: National Heart Lung and Blood Institute (NHLBI); NIH website: https://reporter.nih.gov/project-details/10412013

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