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I am a Professor of Medicine and Section Chief of Pulmonary, Allergy, Critical Care, and Sleep (PACCS) at the Minneapolis VAMC. Our section is a national leader in COPD research. My research has focused on both clinical and translational research in COPD and associated contributors including tobacco, HIV, air pollution and COPD as a causal pathway to lung cancer. For my translational research using a multi-omic approach including genomics, transcriptomics, proteomics, metabolomics, computational and systems biology I have identified biomarkers and causal pathways in COPD leading to lung cancer and HIV-associated COPD. I have participated on five large NIH COPD trials, including the NIH COPD Clinical Research Network and the VA Lung Precision Oncology Program. I have also directed a pilot RCT to explore the role of the microbiome in COPD exacerbations and symptoms. My interest in air pollution and chronic lung disease dates to my participation as a delegate for the University of Minnesota and Chinese Academy of Science to address the health effects of air pollution in China. I have extended this area of research to include epidemiology and respiratory effects of deployment-related air pollution exposure, including burn pit exposure. My research has focused on biomarkers of disease using high-throughput mass spectrometry, specifically focusing on chronic obstructive lung diseases. I have a long-standing interest in clinical and translational research in COPD.