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Minneapolis VA Health Care System Research Service

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Investigator Profile

Person Name

Janeen Trembley, PhD

Positions
Research Health Scientist, Minneapolis VA
Chair, Institutional Animal Care and Use Committee, Minneapolis VA
Adjunct Assistant Professor, Department of Laboratory Medicine and Pathology, University of Minnesota
Education
BA Grinnell College; PhD University of Minnesota
Contact Information
janeen.trembley@va.gov
Research Interests
CK2 and
CDK11
. This work emphasizes defining the roles of these kinases in different cancer types, and the mechanisms by which these molecules contribute to malignant cell signaling. As a member of the Minneapolis VA Oncology Research Group, I have studied cancers of the breast, prostate, head and neck, and skin. The overall goal of these investigations is to understand and exploit cancer cell dependencies on
CK2
and
CDK11
function to improve therapeutic strategies in these malignancies. As a member of the Environmental Exposure Research Group, I am also working on investigating the pathobiology of Chronic Multi-symptom Illness (CMI).
CMI
is a major health concern for Veterans of the Gulf War and those who served in Iraq and Afghanistan. These studies involve measurement of biomarkers in the blood of Veterans as well as in the tissues of rodents exposed to whole body inhalation models of military burn pits. The goals are to define biomarkers of response and understand biological dysregulation following exposures in order to determine possible methods of intervention.
Publications
Full bibliography on PubMed
VA Research Topics
Cancer; Molecular Biology
MeSH Key Words
RNA Polymerase II; Phosphorylation; Casein Kinase II; Cyclin-Dependent Kinases; Signal Transduction; Head and Neck Neoplasms; Melanoma; Prostatic Neoplasms; Breast Neoplasms; RNA Splicing; Mitochondria; Cell Death
Professional Networking
ORCID | ResearchGate | Google Scholar
Links
University of Minnesota profile
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