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Dr. Pardo leads a research program which seeks to elucidate the functional architecture of the human brain with particular emphasis on how dysfunction within neural networks relates to psychiatric disorders. The multidisciplinary approach (in close collaboration with the Brain Sciences Center, Department of Psychology, Department of Psychiatry, and GRECC) involves methods from cognitive neuroscience, including several imaging modalities, particularly fMRI and PET. Brain systems under study in normal subjects include attention and its involvement in memory and affect; language processing and applications to preoperative neurosurgical assessment; and emotional processing through mood induction by cognitive and sensory stimuli. Clinical protocols currently underway seek to relate pathophysiology to the evolving neuroanatomy of the mind. Patient populations include those with mood disorders, schizophrenia, and post traumatic stress disorder.