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Dr. Vijay Mavanji received his Ph.D. in Neurophysiology from the National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India. He joined the Minneapolis VA after completing his post-doctoral training at Boston University school of Medicine. His current research involves the lateral hypothalamus mechanisms involved in the modulation of spontaneous physical activity with special emphasis on orexins. He is also involved in projects aiming to understand the role of orexin in aging, cognitive behavior, obesity and sleep/wake regulation. His recent focus is to determine whether small molecule orexin agonists can be used to treat diseases that are associated with orexin deficiency, and to test whether senolytics can be used to treat infection related complications in vulnerable conditions such as obesity, old age and neurodegeneration.